Zerbrafish as an in vivo model of cardiac development and regeneration
In order to study the in vivo function of lncRNAs and other novel genetic elements, we use a collection of cardiovascular reporter zebrafish lines. Importantly, zebrafish can fully regenerate the heart even after a 20% ventricular amputation. However, the molecular network essential to activate and sustain cardiac regenerative response remains poorly elucidated. We aim to understand the role of lncRNAs in cardiac regeneration of the zebrafish heart, and hope to apply these principles to human cardiac regeneration.